Menu

Javascript is not activated in your browser. This website needs javascript activated to work properly.
You are here

Promising treatment for aggressive childhood cancer

A drug has shown great promise in the treatment of neuroblastoma, an aggressive form of childhood cancer. The study was led by researchers at Lund University in Sweden, and is published in the journal Science Translational Medicine.

Photo of Karin Hansson and Daniel Bexell
Karin Hansson and Daniel Bexell (Photo Åsa Hansdotter)
Every year, about 800 children in the US are diagnosed with neuroblastoma, an aggressive cancer of the nervous system that most frequently arises in the adrenal glands. Despite intensive chemotherapy, the disease can be difficult to cure and the prognosis is often poor. However, researchers at Lund University have now identified and tested a drug that has been shown to be very effective against neuroblastoma.

“Initially we conducted a large-scale drug screen where we examined how 500 drugs affected neuroblastoma cells from patients. Most of these medications have never before been used on patients with neuroblastoma”, says Karin Hansson, doctoral student and first author of the study.

The researchers then obtained a "short list" of the most effective drugs. One of these was a so-called KSP inhibitor, particularly interesting as patients with a high proportion of KSP protein have the more aggressive variant of neuroblastoma, something that is synonymous with a worse prognosis.


When the researchers treated mice with this drug, they saw how the KSP inhibitor prevented tumour growth and drastically prolonged survival. In some cases, the tumour disappeared completely. KSP inhibitors block the protein in tumour cells, meaning that the cells can no longer divide and therefore eventually die.

The KSP inhibitor has not previously been used for neuroblastoma, but was shown to be extra effective against this type of cancer. It also did not affect healthy bone marrow cells, which is important as side effects are a major problem in childhood cancer therapies.

“The results were very clear and the treatment is very promising. But even so, there will probably be a need to combine this treatment with other drugs to completely knock out all tumour cells. Fortunately, the drug is already approved for use in humans. Now, of course, we hope that clinical trials for neuroblastoma will be initiated”, concludes Daniel Bexell, associate professor and research group leader at Lund University.

Publication in Science Translational Medicine: Therapeutic targeting of KSP in preclinical models of high-risk neuroblastoma

Contact:
Daniel Bexell
daniel [dot] bexell [at] med [dot] lu [dot] se

Link to original artikel published by Åsa Hansdotter 27 October 2020

Latest news

23 November 2020

Grants from the Swedish Breast Cancer Association for breast cancer imaging research

Grants from the Swedish Breast Cancer Association for breast cancer imaging research
13 November 2020

In the wake of the pandemic: new methods of cancer care

In the wake of the pandemic: new methods of cancer care
13 November 2020

Promising treatment for aggressive childhood cancer

Promising treatment for aggressive childhood cancer
13 November 2020

New analytical model detects mutations in breast cancer

New analytical model detects mutations in breast cancer
12 October 2020

LUCC researcher receive ERC Starting Grant

LUCC researcher receive ERC Starting Grant

LUCC - Lund University Cancer Centre
Lund University
Box 117, 221 00, Lund, Sweden
Telephone +46 (0) 46 222 0000 (switchboard)